Biological Roles of Acid and Neutral Sphingomyelinases and Their Regulation by Nitric Oxide Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases
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چکیده
Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors. Cristiana Perrotta and Emilio Clementi Unit of Clinical Pharmacology, Department of Preclinical Sciences, University Hospital “Luigi Sacco,” Università di Milano, Milano; and E. Medea Scientific Institute, Bosisio Parini, Italy [email protected]
منابع مشابه
Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide.
Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by su...
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